Immune Health

Mushroom dietary supplements

Mushroom dietary supplements


What are functional mushrooms?

Functional mushrooms are non-psychoactive mushroom species grown worldwide. They are rich in vitamins, minerals, fiber, antioxidants, and protein. In addition to their use as food, these mushrooms have been considered “medicine” in certain cultures for centuries. 

Today, functional mushrooms appear as ingredients in dietary supplement products marketed for overall health and wellness. Species commonly listed on dietary supplement labels are lion’s mane, turkey tail, reishi, cordyceps, shiitake, chaga, and maitake. 

These functional mushrooms are commonly sold as powders or extracts, with the fruiting body (the part usually visible above ground) or mycelium (the ‘root’ of the mushroom) listed on the label. Chemical compounds (such as polysaccharides, glucans, and triterpenes) found in both the fruiting body and the mycelium are often credited with the mushroom’s marketed benefits. 

What are the marketed benefits of functional mushroom dietary supplements?

  • Immune health
  • Brain and cognitive function
  • Energy
  • Blood sugar control
  • Gut health
  • Cellular health
  • Inflammatory health

It remains unclear if mushrooms in the form of dietary supplements deliver the same chemical components or biological effects as eating whole mushrooms. Currently, there is a lack of scientific evidence to support the use of functional mushrooms for any purpose other than as a food.

Safety and Considerations

  • There is currently limited information available to support the safety of functional mushrooms when used as ingredients in dietary supplement products.
    • The quality and purity of mushroom extracts and powders may vary greatly, depending on many factors, including processing steps and growing conditions.
    • Some dietary supplement products may combine multiple different types of mushrooms into a single product or a proprietary blend. There is little to no safety data regarding how these combinations of mushrooms might interact in the body.
  • Side effects reported from using functional mushroom dietary supplement products include nausea, vomiting, diarrhea, gastrointestinal (GI) discomfort, dry mouth, and allergic reactions.

While the functional mushrooms listed above are intended to support daily wellness, a different and riskier category of mushroom products has recently emerged. These products often blur the lines between health supplements and recreational substances, using marketing specifically designed to target consumers looking for a “legal high.”

Beware of mushroom dietary supplements that are marketed as a “legal high”

  • Marketing language for these “magic mushroom” products often includes “euphoric buzz,” “legal psychedelic high,” “refreshing trip,” “mind-melting,” and “microdose.”
    • Despite claims of “no illegal ingredients,” Service Members and consumers should be aware that these products may contain prohibited or harmful substances.
    • “Magic mushroom” ingredients can impair performance and cause significant health risks, including vomiting, confusion, loss of consciousness, and seizures.
    • Per DoDI 1010.04, the use of any substance intended to alter one’s mental state or state of consciousness is prohibited for use by Service Members.

Are functional mushrooms prohibited for Service Members?

  • Functional mushrooms such as lion’s mane, turkey tail, reishi, cordyceps, shiitake, chaga, and maitake are not prohibited for use by Service Members. 
  • However, “magic mushroom” products may contain prohibited ingredients including Amanita muscaria, muscarine, ibotenic acid, muscimol, psilocybin, and psilocin. 

Bottom Line

  • Functional mushrooms (examples listed above) are not prohibited for use by Service Members. 
  • There is not enough scientific evidence to support the safety or effectiveness of functional mushrooms for any use other than as food. 
  • “Magic mushroom” products can seriously harm your health and career. 

Additional Resources

Posted 2 April 2026