If you’ve ever eaten something spicy and felt a burning sensation on your tongue, then you’ve eaten capsaicinoids. Capsaicinoids (including capsaicin, dihydrocapsaicin, and others) are the substances found in chili peppers that give them their spiciness. Although humans have been eating peppers for thousands of years, capsaicinoids only recently have come into the supplement spotlight. As a dietary supplement ingredient, capsaicinoids are often labeled as “cayenne pepper” or “capsicum,” after the family of peppers that naturally contain capsaicinoids.

Is capsaicin in dietary supplements effective for weight loss?

Capsaicinoids are purported to aid weight loss in three ways: increase energy use, burn fat, and decrease appetite. Some scientific evidence supports these statements, but results are mixed, and many studies only looked at the short-term effects of consuming capsaicinoids. Whether capsaicinoids can affect metabolism and appetite enough to result in meaningful weight loss or help with weight maintenance remains in question.

There isn’t enough evidence to support the use of capsaicin or capsaicinoids for weight loss.

Moreover, additional research would be needed to determine the optimal dose and duration of capsaicinioids for weight loss. Consuming too much capsaicinoids (whether from food or supplements) can cause gastrointestinal issues for some people. Also, long-term effects of taking supplemental capsaicinoids, especially at high doses, are still unknown, so their safety over time needs further investigation.

More research is needed to determine if capsaicinoids can help you lose weight, but if you still want to include them as part of a healthy diet, try adding some chili peppers to your foods, but only as much as you can tolerate and enjoy.


Updated 06 January 2021


Hochkogler, C. M., Lieder, B., Rust, P., Berry, D., Meier, S. M., Pignitter, M., . . . Somoza, V. (2017). A 12-week intervention with nonivamide, a TRPV1 agonist, prevents a dietary-induced body fat gain and increases peripheral serotonin in moderately overweight subjects. Molecular Nutrition & Food Research, 61(5), 1600731. doi:10.1002/mnfr.201600731

Lejeune, M. P. G. M., Kovacs, E. M. R., & Westerterp-Plantenga, M. S. (2003). Effect of capsaicin on substrate oxidation and weight maintenance after modest body-weight loss in human subjects. British Journal of Nutrition, 90(03), 651–659. doi:10.1079/bjn2003938

Ludy, M.-J., & Mattes, R. D. (2011). The effects of hedonically acceptable red pepper doses on thermogenesis and appetite. Physiology & Behavior, 102(3-4), 251–258. doi:10.1016/j.physbeh.2010.11.018

Ludy, M. J., Moore, G. E., & Mattes, R. D. (2011). The effects of capsaicin and capsiate on energy balance: Critical review and meta-analyses of studies in humans. Chemical Senses, 37(2), 103–121. doi:10.1093/chemse/bjr100

OmniActive Health Technologies. Capsimax.   Retrieved 30 April 2019 from http://omniactives.com/product/capsimax/

Osuna-Prieto, F. J., Martinez-Tellez, B., Sanchez-Delgado, G., Aguilera, C. M., Lozano-Sánchez, J., Arráez-Román, D., . . . Ruiz, J. R. (2019). Activation of human brown adipose tissue by capsinoids, catechins, ephedrine, and other dietary components: A systematic review. Advances in Nutrition, 10(2), 291–302. doi:10.1093/advances/nmy067

Schwarz, N. A., Spillane, M., La Bounty, P., Grandjean, P. W., Leutholtz, B., & Willoughby, D. S. (2013). Capsaicin and evodiamine ingestion does not augment energy expenditure and fat oxidation at rest or after moderately-intense exercise. Nutrition Research, 33(12), 1034–1042. doi:10.1016/j.nutres.2013.08.007

Smeets, A. J., Janssens, P. L. H. R., & Westerterp-Plantenga, M. S. (2013). Addition of capsaicin and exchange of carbohydrate with protein counteract energy intake restriction effects on fullness and energy expenditure. Journal of Nutrition, 143(4), 442–447. doi:10.3945/jn.112.170613

Smeets, A. J., & Westerterp-Plantenga, M. S. (2009). The acute effects of a lunch containing capsaicin on energy and substrate utilisation, hormones, and satiety. European Journal of Nutrition, 48(4), 229–234. doi:10.1007/s00394-009-0006-1

Stuby, J., Gravestock, I., Wolfram, E., Pichierri, G., Steurer, J., & Burgstaller, J. M. (2019). Appetite-suppressing and satiety-increasing bioactive phytochemicals: A systematic review. Nutrients, 11(9), Article 2238. doi:10.3390/nu11092238

Tomé, D., Janssens, P. L. H. R., Hursel, R., Martens, E. A. P., & Westerterp-Plantenga, M. S. (2013). Acute effects of capsaicin on energy expenditure and fat oxidation in negative energy balance. PLoS ONE, 8(7), e67786. doi:10.1371/journal.pone.0067786

Urbina, S. L., Roberts, M. D., Kephart, W. C., Villa, K. B., Santos, E. N., Olivencia, A. M., . . . Wilborn, C. D. (2017). Effects of twelve weeks of capsaicinoid supplementation on body composition, appetite and self-reported caloric intake in overweight individuals. Appetite, 113, 264–273. doi:10.1016/j.appet.2017.02.025

van Avesaat, M., Troost, F. J., Westerterp-Plantenga, M. S., Helyes, Z., Le Roux, C. W., Dekker, J., . . . Keszthelyi, D. (2016). Capsaicin-induced satiety is associated with gastrointestinal distress but not with the release of satiety hormones. The American Journal of Clinical Nutrition, 103(2), 305–313. doi:10.3945/ajcn.115.123414

Westerterp-Plantenga, M. S. (2020). Challenging energy balance - during sensitivity to food reward and modulatory factors implying a risk for overweight - during body weight management including dietary restraint and medium-high protein diets. Physiology & Behavior, 221, Article 112879. doi:10.1016/j.physbeh.2020.112879

Whiting, S., Derbyshire, E., & Tiwari, B. K. (2012). Capsaicinoids and capsinoids. A potential role for weight management? A systematic review of the evidence. Appetite, 59(2), 341–348. doi:10.1016/j.appet.2012.05.015

Whiting, S., Derbyshire, E. J., & Tiwari, B. (2014). Could capsaicinoids help to support weight management? A systematic review and meta-analysis of energy intake data. Appetite, 73, 183–188. doi:10.1016/j.appet.2013.11.005

Zsiborás, C., Mátics, R., Hegyi, P., Balaskó, M., Pétervári, E., Szabó, I., . . . Solymár, M. (2017). Capsaicin and capsiate could be appropriate agents for treatment of obesity: A meta-analysis of human studies. Critical Reviews in Food Science and Nutrition, 58(9), 1419–1427. doi:10.1080/10408398.2016.1262324