Mushrooms are a type of fungus grown worldwide. They are rich in vitamins, minerals, fiber, antioxidants, and protein. While you might first think of mushrooms as food, they have been used as “medicine” for centuries. Today, mushrooms are also used as ingredients in dietary supplement products.

Many different types of mushrooms are found on dietary supplement labels, but the most common are reishi, shiitake, Cordyceps sinensis, maitake, Cordyceps militaris, lion’s mane, chaga, and turkey tail. Regardless of what type they contain, mushroom supplements are marketed for numerous health benefits. Some claims are general, such as promoting vitality and immune health. Others are more specific, such as promoting healthy cellular function, enhancing cognitive performance, controlling blood sugar levels, aiding digestion, and supporting a healthy inflammatory response by the liver.  

The mushrooms used in dietary supplements are marketed for numerous health benefits, but there isn’t enough scientific evidence to support their safety or use for any specific purpose, except as a food.

When mushrooms are used in dietary supplements, they are often in the form of a powder or extract. The “fruiting body” often mentioned on labels is the part usually visible above ground—the part you would typically eat as a food. The mycelium, also sometimes mentioned on labels, is the “root” of the mushroom; it can be grown more quickly and easily than the fruiting body. They both contain beneficial chemical components (polysaccarides, glucans, triterpenes etc.). However, it remains unclear if mushrooms in the form of dietary supplements deliver the same components or biological effects as when eating mushrooms as food.

Mushroom extracts and powders can be produced in a variety of ways. Generally, extracts can be made by boiling fruiting bodies in hot water or alcohol. Powders can be made by grinding up the dried mycelium or fruiting body. The different processing methods and various growing conditions (in logs, sawdust, liquid, etc.) make it difficult to control and standardize the chemical makeup of these mushroom-based ingredients, which can potentially compromise both quality and consistency among batches and products.

Are mushroom dietary supplements safe or effective?

Generally, mushrooms as a food are safe to consume, but some types can be poisonous (toxic). Consuming toxic mushrooms can result in severe side effects such as nausea, diarrhea, vomitting, liver failure, and in some cases, death. Dietary supplement products shouldn’t contain poisonous mushrooms, but without laboratory testing, it is difficult to know for sure.

Currently there isn’t enough reliable information available to support the safety, effectiveness, or appropriate use of dietary supplements that contain non-toxic mushrooms. Some dietary supplement labels with mushroom ingredients carry warning statements such as, “Avoid using if you’re pregnant, breastfeeding, or anticipate surgery.” Side effects reported from using such products include such as nausea, vomitting, diarrhea, dizziness, skin sensitivity, headache, gastrointestinal (GI) discomfort, and allergic reactions.

Are mushrooms prohibited for use?

Mushrooms suitable for use as food or dietary supplement ingredients are not prohibited for use by Military Service Members. However, some mushrooms contain the controlled substance psilocybin (or psilocin). In addition, “magic mushroom” products can contain other plant-based hallucinogens (some of which are also controlled substances) and might not even contain mushrooms. Military Service Members are prohibited from using any controlled substance and any substance with mind-altering properties.


Updated 29 July 2020


Academy of Nutrition and Dietetics. (2019). Fun with funghi: Garnish your meals with mushrooms.   Retrieved 16 July 2020 from

Chang, S. T., & Wasser, S. P. (2018). Current and future research trends in agricultural and biomedical applications of medicinal mushrooms and mushroom products (Review). International Journal of Medicinal Mushrooms, 20(12), 1121–1133. doi:10.1615/IntJMedMushrooms.2018029378

Coy, C., Standish, L. J., Bender, G., & Lu, H. (2015). Significant correlation between TLR2 agonist activity and TNF-α induction in J774.A1 macrophage cells by different medicinal mushroom products. International Journal of Medicinal Mushrooms, 17(8), 713–722. doi:10.1615/IntJMedMushrooms.v17.i8.20

Gaullier, J.-M., Sleboda, J., Ofjord, E. S., Ulvestad, E., Nurminiemi, M., Moe, C., . . . Gudmundsen, O. (2011). Supplementation with a soluble beta-glucan exported from shiitake medicinal mushroom, Lentinus edodes (Berk.) Singer mycelium: A crossover, placebo-controlled study in healthy elderly. International Journal of Medicinal Mushrooms, 13(4), 319–326. doi:10.1615/IntJMedMushr.v13.i4.10

Gründemann, C., Reinhardt, J. K., & Lindequist, U. (2020). European medicinal mushrooms: Do they have potential for modern medicine? – An update. Phytomedicine, 66, Article 153131. doi:10.1016/j.phymed.2019.153131

Klupp, N. L., Chang, D., Hawke, F., Kiat, H., Cao, H., Grant, S. J., & Bensoussan, A. (2015). Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database of Systematic Reviews(2), Article CD007259. doi:10.1002/14651858.CD007259.pub2

Kothari, D., Patel, S., & Kim, S.-K. (2018). Anticancer and other therapeutic relevance of mushroom polysaccharides: A holistic appraisal. Biomedicine & Pharmacotherapy, 105, 377–394. doi:10.1016/j.biopha.2018.05.138

Rathore, H., Prasad, S., Kapri, M., Tiwari, A., & Sharma, S. (2019). Medicinal importance of mushroom mycelium: Mechanisms and applications. Journal of Functional Foods, 56, 182–193. doi:10.1016/j.jff.2019.03.016

Reis, F. S., Barros, L., Martins, A., & Ferreira, I. C. F. R. (2012). Chemical composition and nutritional value of the most widely appreciated cultivated mushrooms: An inter-species comparative study. Food and Chemical Toxicology, 50(2), 191–197. doi:10.1016/j.fct.2011.10.056

Saitsu, Y., Nishide, A., Kikushima, K., Shimizu, K., & Ohnuki, K. (2019). Improvement of cognitive functions by oral intake of Hericium erinaceus. Biomedical Research, 40(4), 125–131. doi:10.2220/biomedres.40.125

Tang, C., Hoo, P. C.-X., Tan, L. T.-H., Pusparajah, P., Khan, T. M., Lee, L.-H., . . . Chan, K.-G. (2016). Golden needle mushroom: A culinary medicine with evidenced-based biological activities and health promoting properties. Frontiers in Pharmacology, 7, Article 474. doi:10.3389/fphar.2016.00474

The Mushroom Council. Mushrooms and your health.   Retrieved 16 July 2020 from

U.S. Food & Drug Administration. (1988). CPG Sec 585.525: Mushroom Mycelium - Fitness for Food; Labeling.   Retrieved 16 July 2020 from

Ulziijargal, E., & Mau, J.-L. (2011). Nutrient compositions of culinary-medicinal mushroom fruiting bodies and mycelia. International Journal of Medicinal Mushrooms, 13(4), 343–349. doi:10.1615/IntJMedMushr.v13.i4.40

VanderMolen, K. M., Little, J. G., Sica, V. P., El-Elimat, T., Raja, H. A., Oberlies, N. H., . . . Mahony, C. (2017). Safety assessment of mushrooms in dietary supplements by combining analytical data with in silico toxicology evaluation. Food and Chemical Toxicology, 103, 133–147. doi:10.1016/j.fct.2017.03.005

Vetvicka, V., Vannucci, L., Sima, P., & Richter, J. (2019). Beta glucan: Supplement or drug? From laboratory to clinical trials. Molecules, 24(7), Article 1251. doi:10.3390/molecules24071251

Wu, D.-T., Deng, Y., Chen, L.-X., Zhao, J., Bzhelyansky, A., & Li, S.-P. (2017). Evaluation on quality consistency of Ganoderma lucidum dietary supplements collected in the United States. Scientific Reports, 7(1), Article 7792. doi:10.1038/s41598-017-06336-3