Maybe you’ve heard of omega-3s, but there’s another kind of fatty acid that’s available in dietary supplements: omega-7s, a type of unsaturated fat your body makes. Omega-7s are considered non-essential fatty acids, meaning your body can make enough omega-7s to function properly. In other words, you don’t need to get them from foods or supplements. However, if you search for omega-7 supplements on the Internet, you’ll find pages of results of articles and online retailers purporting the beneficial effects of omega-7 fatty acids (particularly from sea buckthorn oil), such as for heart, digestive, and liver health, immune support, weight loss, detoxification, glucose (blood sugar) metabolism, hydration of mucous membranes, and healthy skin, hair, and nails.

One of the most common forms of omega-7s is palmitoleic acid, which also is found in a few foods, including macadamia, sea buckthorn, and some fish, such as salmon and cod. In the body, palmitoleic acid plays a role in fat metabolism, and research suggests it also might have a role in insulin sensitivity and cholesterol metabolism. However, data are mixed on how the palmitoleic acid made in your body impacts your health.

With regard to supplemental omega-7, a limited amount of research using isolated cells and animals suggests that an external source of palmitoleic acid (by mouth in a dietary supplement or by injection) can increase fatty-acid breakdown and energy expenditure, reduce weight gain and food intake, and improve insulin sensitivity and glucose metabolism. But there hasn’t been enough research on either omega-7 or palmitoleic acid supplements in humans to to determine if they’re effective. As a result, no recommended dose or source of omega-7s or palmitoleic acid has been established so far.

 

Content current as of 30 January 2023

References

Basu, S., Trieu, K., Bhat, S., Dai, Z., Leander, K., Gigante, B., . . . Marklund, M. (2021). Biomarkers of dairy fat intake, incident cardiovascular disease, and all-cause mortality: A cohort study, systematic review, and meta-analysis. PLOS Medicine, 18(9), article e1003763. doi:10.1371/journal.pmed.1003763

de Nazaré Santos Torres, R., Bertoco, J. P. A., Arruda, M. C. G., de Melo Coelho, L., Paschoaloto, J. R., Ezequiel, J. M. B., & Almeida, M. T. C. (2021). The effect of dietary inclusion of crude glycerin on performance, ruminal fermentation, meat quality and fatty acid profile of beef cattle: Meta-analysis. Research in Veterinary Science, 140, 171–184. doi:10.1016/j.rvsc.2021.08.019

de Souza, C. O., Vannice, G. K., Rosa Neto, J. C., & Calder, P. C. (2018). Is palmitoleic acid a plausible nonpharmacological strategy to prevent or control chronic metabolic and inflammatory disorders? Molecular Nutrition & Food Research, 62(1), article 1700504. doi:10.1002/mnfr.201700504

Deng, Y., Wang, L., Huang, J., Ding, H., & Wong, M. C. S. (2022). Associations between potential causal factors and colorectal cancer risk: A systematic review and meta‐analysis of Mendelian randomization studies. Journal of Digestive Diseases, 23(8-9), 435–445. doi:10.1111/1751-2980.13130

Frigolet, M. E., & Gutiérrez-Aguilar, R. (2017). The role of the novel lipokine palmitoleic acid in health and disease. Advances in Nutrition: An International Review Journal, 8(1), 173S–181S. doi:10.3945/an.115.011130

Hosseinkhani, S., Dehghanbanadaki, H., Aazami, H., Pasalar, P., Asadi, M., & Razi, F. (2021). Association of circulating omega 3, 6 and 9 fatty acids with gestational diabetes mellitus: A systematic review. BMC Endocrine Disorders, 21(1), article 120. doi:10.1186/s12902-021-00783-w

Larmo, P. S., Järvinen, R. L., Setälä, N. L., Yang, B., Viitanen, M. H., Engblom, J. R. K., . . . Kallio, H. P. (2010). Oral sea buckthorn oil attenuates tear film osmolarity and symptoms in individuals with dry eye. The Journal of Nutrition, 140(8), 1462–1468. doi:10.3945/jn.109.118901

Larmo, P. S., Kangas, A. J., Soininen, P., Lehtonen, H.-M., Suomela, J.-P., Yang, B., . . . Kallio, H. P. (2013). Effects of sea buckthorn and bilberry on serum metabolites differ according to baseline metabolic profiles in overweight women: A randomized crossover trial. The American Journal of Clinical Nutrition, 98(4), 941–951. doi:10.3945/ajcn.113.060590

Larmo, P. S., Yang, B., Hurme, S. A. M., Alin, J. A., Kallio, H. P., Salminen, E. K., & Tahvonen, R. L. (2009). Effect of a low dose of sea buckthorn berries on circulating concentrations of cholesterol, triacylglycerols, and flavonols in healthy adults. European Journal of Nutrition, 48(5), 277–282. doi:10.1007/s00394-009-0011-4

Larmo, P. S., Yang, B., Hyssälä, J., Kallio, H. P., & Erkkola, R. (2014). Effects of sea buckthorn oil intake on vaginal atrophy in postmenopausal women: A randomized, double-blind, placebo-controlled study. Maturitas, 79(3), 316–321. doi:10.1016/j.maturitas.2014.07.010

Lehtonen, H. M., Suomela, J. P., Tahvonen, R., Yang, B., Venojärvi, M., Viikari, J., & Kallio, H. (2011). Different berries and berry fractions have various but slightly positive effects on the associated variables of metabolic diseases on overweight and obese women. European Journal of Clinical Nutrition, 65(3), 394–401. doi:10.1038/ejcn.2010.268

Matthan, N. R., Dillard, A., Lecker, J. L., Ip, B., & Lichtenstein, A. H. (2009). Effects of dietary palmitoleic acid on plasma lipoprotein profile and aortic cholesterol accumulation are similar to those of other unsaturated fatty acids in the F1B Golden Syrian hamster. The Journal of Nutrition, 139(2), 215–221. doi:10.3945/jn.108.099804

Nunes, E., & Rafacho, A. (2017). Implications of palmitoleic acid (palmitoleate) on glucose homeostasis, insulin resistance and diabetes. Current Drug Targets, 18(6), 619–628. doi:10.2174/1389450117666151209120345

Olas, B., Skalski, B., & Ulanowska, K. (2018). The anticancer activity of sea buckthorn [Elaeagnus rhamnoides (L.) A. Nelson]. Frontiers in Pharmacology, 9, 232. doi:10.3389/fphar.2018.00232

Susan, D., Volpi Lagreca, G., Alende, M., & Long, N. (2014). Palmitoleic acid reduces intramuscular lipid and restores insulin sensitivity in obese sheep. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2014(7), 553–563. doi:10.2147/dmso.S72695

Yang, Z.-H., Miyahara, H., & Hatanaka, A. (2011). Chronic administration of palmitoleic acid reduces insulin resistance and hepatic lipid accumulation in KK-Ay mice with genetic type 2 diabetes. Lipids in Health and Disease, 10(1), 120. doi:10.1186/1476-511x-10-120

Yang, Z.-H., Takeo, J., & Katayama, M. (2013). Oral administration of omega-7 palmitoleic acid induces satiety and the release of appetite-related hormones in male rats. Appetite, 65(1 June), 1–7. doi:10.1016/j.appet.2013.01.009