Performance Enhancing Substance: MK-677 (Ibutamoren)
MK-677, also known as Ibutamoren, is a “growth hormone secretagogue,” a substance that stimulates the production of growth hormone. It is not approved for human use, which makes it an unapproved drug. It is also not legal for use as an ingredient in dietary supplements or any other consumer or commercial products. It can only be used for research purposes.
MK-677 is on the DoD Prohibited Dietary Supplement Ingredients List and the World Anti-Doping Agency Prohibited List. It is not legal for use.
The Food and Drug Administration (FDA) has posted warning letters to companies illegally selling products containing MK-677. These types of products are sometimes labeled as dietary supplements with a “Supplement Facts” label, as a research chemical with a “Research Facts” label, or even labeled as “For Research Use Only.”
Even though it is illegal, MK-677 is currently marketed with claims to help build muscle or increase muscle mass, decrease body fat, and increase energy. In addition, products that contain MK-677 are often combined with SARMs (or even indicate MK-677 as a SARM). SARMs are also illegal and prohibited for use.
What are the safety concerns?
A number of health risks have been associated with the use of MK-677 (Ibutamoren).
- FDA lists Ibutamoren as an ingredient that “…poses significant safety risks due to the potential for congestive heart failure in certain patients.” A clinical trial was stopped early due to concerns that Ibutamoren may increase the rate of heart failure.
- Ibutamoren is listed in the Australian Poisons Standard. The long-term safety is not established and the potential adverse effects “…may include those associated with the administration of growth hormones and the potential for downstream health effects such as cardiovascular and hormonal effects.”
- MK-677 has also been reported to negatively impact bone and bone mineral density, increase fasting blood glucose levels, heighten the risk of hyperglycemia, and affect insulin sensitivity.
- Other side effects include anxiety, diarrhea, increased fluid retention and swelling, increased hunger, muscle or joint pain, numbness, and nausea.
- When combined with SARMs, MK-677 could negatively impact serum lipids, liver enzymes, testosterone levels, or worse. SARMs (on their own) are known to be associated with serious safety concerns, including the potential to increase the risk of heart attack or stroke and life-threatening reactions such as liver damage.
Can MK-677 negatively affect a Service Member’s career?
Not only is use of MK-677 a health risk, but it could adversely affect a career.
- MK-677 is prohibited for use in the military and is on the DoD Prohibited Dietary Supplement Ingredients List and the World Anti-Doping Agency Prohibited List. Therefore, Service Members should not use any products with this ingredient.
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Posted 23 February 2024
