If you’ve ever eaten something spicy and felt a burning sensation on your tongue, then you’ve eaten capsaicinoids. Capsaicinoids (including capsaicin, dihydrocapsaicin, and others) are the substances found in chili peppers that give them their spiciness. Although humans have been eating peppers for thousands of years, capsaicinoids only recently have come into the supplement spotlight. As a dietary supplement ingredient, capsaicinoids are often labeled as “cayenne pepper” or “capsicum,” after the family of peppers that naturally contain capsaicinoids.